Leyton Orient were knocked out of the Carabao Cup at the first-round stage after suffering a 2-0 loss against League Two leaders Plymouth Argyle.

Ryan Lowe's side scored twice in quick succession in the second half to condemn the O's to defeat, firstly through Callum McFadzean and then via Dom Telford.

Ross Embleton made four changes to the side that lost at Macclesfield Town on Saturday. Joe Widdowson returned from injury at left-back, new signing Louis Dennis made his first start, and Dale Gorman and Myles Judd came in for Sam Ling and James Brophy.

A nervy start from the visitors saw Argyle create the first chance of the game but Ryan Taylor couldn't keep his close-range header on target.

Danny Mayor, one of the many Bury players to have followed manager Lowe down to Devon, then sent in a dangerous cross, but Dan Happe was on hand to clear the danger.

It was all Plymouth even as the half went on, and they had another opportunity to take the lead after 20 minutes, but Telford's effort from outside the box curled just wide.

Orient's first real chance of the contest didn't come until the 40-minute mark, but Mike Cooper was equal to Marvin Ekpiteta's effort.

Despite making the brighter start to the second half, Orient fell behind just before the hour mark when McFadzean picked the ball up on the edge of the area and powered into the top corner.

That lead was doubled just minutes later to put the game out of site, Telford racing through to finish into the bottom corner.

Happe came close to pulling one back at the end but he couldn't divert Brophy's corner goalwards, meaning Orient go out at the first round stage as they did in their previous two appearances, and now prepare for their league fixture at home to Stevenage this Saturday.