Michail Antonio returns to the West Ham squad for the trip to Southampton.
The winger underwent a hamstring operation over the summer and was not ready for last Sunday's 4-0 defeat against Manchester United, but he will feature at St Mary's.
Midfielders Cheikhou Kouyate and Manuel Lanzini (both knee) and striker Andy Carroll (thigh) remain sidelined, although all three are back in training.
Provisional squad: Hart, Adrian, Cresswell, Ogbonna, Reid, Fonte, Collins, Zabaleta, Byram, Masuaku, Noble, Fernandes, Obiang, Rice, Arnautovic, Antonio, Ayew, Hernandez, Sakho.
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