The Guardian Series is hoping fans will enjoy interacting pre-match, during the game and after the final whistle has blown on our website.

Twitter users can contribute just by adding the #lofc hashtag and for those of you not on the social networking site, you can still read the comments here and add your own views in the comment section below.

If you have any questions for our reporter about the match or other Orient related matters then you can contact him via Twitter by tweeting @GuardianOrient.

Key points

•The O's make three changes with Jimmy Smith, Moses Odubajo and Shaun Batt in for Lee Cook, Charlie MacDonald and David Mooney.

• Leyton Orient have slipped down to mid-table after losing their last two League One games. 

Sheffield United line-up

Long; McMahon, Maguire, Collins, Higginbotham; Flynn, McDonald, Doyle, Robson (De Girolamo, 72); Poleon (McFadzean, 63), Kitson (Cresswell, 72)

Subs not used: Westlake, Hill, Ironside, Coyne 

Leyton Orient line-up 

Jones; McSweeney, Clarke, Baudry, Cuthbert; Cox, Vincelot, Smith, James, Odubajo; Batt (Mooney, 56)

Subs not used: Griffith, MacDonald, Grainger, Obafemi, Cook, Omozusi