No one has used the government's Help to Buy scheme in Walthamstow, Leyton or Wanstead, according to new figures.
There was no participation in the scheme in the parliamentary constituencies of Leyton and Wanstead, and Walthamstow, between June 2013 and July 2014, statistics released by Open Data Communities shows.
The zero uptake could also be found in both Ilford North and South during the same period, following analysis of data gathered by the Office of National Statistics.
A total of 37 housebuyers took advantage of the scheme in Chingford and Woodford Green, and five in Epping Forest.
Help to Buy was set up by the government last year to help first-time buyers get on the property ladder, with equity loans to help them obtain their first mortgage.
The scheme was most popular in the constituency of Northwest Cambridgeshire, where 279 people signed up.
Leyton and Wanstead MP John Cryer believes figures from his constituency are due to rising house prices and a fall in incomes.
He said: “It’s no surprise that nobody in Leyton and Wanstead has taken up the Help to Buy scheme.
"For all the talk of a recovery, most of my constituents have seen their incomes fall in real terms and they are increasingly having to rely on zero hours jobs, with no reliable or consistent level of income.
"Anybody who considered the scheme probably decided that they could not afford to take on that level of debt.
“Property prices are far too high in London and the South East and they are still rising, that is the main factor putting off first time buyers, and Help to Buy simply does not address this."